Endocrine Abstracts

A 30-year-old female reported a 2-year history of excessive sweating / flushing affecting the right hand side of the face and scalp along with the right arm. These symptoms were generally related to exercise and demonstrated a sharp midline demarcation, being present only on the right hand side.Past medical history included hypothyroidism secondary to Hashimoto’s Thyroiditis. She was euthyroid on levothyroxine. She also reported unequal pupils since...

An 80-year old female was admitted to Ipswich Hospital with anorexia, constipation, thirst and fatigue. Her examination was unremarkable apart from 2 cm splenomegaly. Investigations revealed renal impairment (creatinine 293 umol/l), normal electrolytes along with hypercalcaemia (corrected Ca 3.54 mmol/l), normal PO4, normal CXR, PTH of 3.3 pmol/l (NR -normal range- 0.95–5.7 pmol/l) and protein electrophoresis was normal. Abdominal USS confirmed splenomegaly. Af...

Introduction: Grave”s disease (GD) is a common cause of thyrotoxicosis, Myasthenia Gravis (MG) is less common (incidence of 3-30cases per million). Between 5-10% of patients with MG also have thyroid disease. However, only 0.14% of patients with GD having MG. Both are autoimmune diseases sharing pathophysiological mechanisms. Co-existence, although rare, is well established. MG may mimic the neuromuscular signs of GD especially if these are subtle. We report a case of a 3...

Case history: A 26-year-old man was referred to the Endocrine Clinic due to lack of erections and infrequent shaving for 12 months. An extensive past medical history was noted, the majority of which was attributed to a diagnosis of cerebral palsy. Problems included feeding difficulties from birth with NG, followed by PEG feeding from age 3 to 20, gross motor, speech and language developmental delay, bilateral severe hearing impairment necessitating hearing aids, long sightedne...

A 65-year-old female, with a 4 month history of left upper quadrant discomfort, was identified as having a multi-loculated para-renal ‘cyst’ on ultrasound scanning. CT identified a 13×11×10 cm heterogeneous mass arising from the left adrenal. An enlarged ill-defined left retro-crural ‘lymph node’ was also noted. There was no history of weight loss. Past medical history was unremarkable. She was no medication. Examination was unremarkable apart fro...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is regarded as a precursor to the development of carcinoid tumorlets. It is confined to the neuroendocrine cell of the airway mucosa without penetration through the basement membrane and appears in a diffuse pattern, typically in association with obliterative bronchiolar fibrosis. DIPNECH belongs to the preinvasive lesions defined by the 1999 World Health Organization classification, along with atypical ade...

Section 1: Case history: A 38 year old female was identified as carrying a heterozygous pathogenic MEN1 variant (c.13404delG) through predictive testing, following a diagnosis of familial hyperparathyroidism.Section 2: Investigations: Routine screening for hyperparathyroidism and pituitary disease was negative. However, a CT thorax–abdomen–pelvis revealed a 41 mm pancreatic tail mass. Biopsy via endoscopic ultrasound confirmed a well-d...

A 38 year old female was identified as carrying a heterozygous pathogenic MEN1 variant (c.13404delG) through predictive testing, following a diagnosis of familial hyperparathyroidism. Routine screening for hyperparathyroidism and pituitary disease was negative. However, a CT thorax-abdomen-pelvis revealed a 41 mm pancreatic tail mass. Biopsy via endoscopic ultrasound confirmed a well-differentiated (grade 1) pancreatic neuroendocrine tumour (pNET) with MIB1<1%. Bi...